What are the clinical manifestations in the patient with Cushing syndrome caused by excessive levels of circulating cortisol?

1. What are the clinical manifestations in the patient with Cushing syndrome caused by excessive levels of circulating cortisol? Which gland(s) may be responsible for the disease? Why must the patient on large doses of glucocorticoids for another disease be monitored for Cushing syndrome?

2. What known medical history data makes an individual a high risk for thyroid cancer?

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